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TAS-103 (dihydrochloride)
CAS No. 174634-09-4
TAS-103 (dihydrochloride)( BMS-247615 dihydrochloride )
Catalog No. M20657 CAS No. 174634-09-4
TAS-103 (dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 80 | In Stock |
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| 10MG | 120 | In Stock |
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| 25MG | 259 | In Stock |
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| 50MG | 385 | In Stock |
|
| 100MG | 575 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTAS-103 (dihydrochloride)
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NoteResearch use only, not for human use.
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Brief DescriptionTAS-103 (dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.
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DescriptionTAS-103 (dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.
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In VitroTAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103. TAS-103 inhibits the viability of HeLa cells, with an IC50 of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation.
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In VivoTAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103.
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SynonymsBMS-247615 dihydrochloride
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PathwayCell Cycle/DNA Damage
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TargetTopoisomerase
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Recptortopo I/II
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Research Area——
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Indication——
Chemical Information
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CAS Number174634-09-4
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Formula Weight406.31
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Molecular FormulaC20H21Cl2N3O2
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Purity>98% (HPLC)
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SolubilityH2O:50 mg/mL (123.06 mM; Need ultrasonic)
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SMILESCl.Cl.CN(C)CCNc1nc2cc(O)ccc2c2-c3ccccc3C(=O)c12
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Chemical Name.6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno[21-c]quinolin-7-one dihydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Aoyagi Y Kobunai T Utsugi T et al. In vitro Antitumor Activity of TAS-103 a Novel Quinoline Derivative That Targets Topoisomerases I and II[J]. Japanese journal of cancer research: Gann 1999 90(5):578-587.
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